Biomolecular Machines Laboratory

Molecular machines are nanoscale macromolecular complexes performing specific functions for an organism. Living cells build thousands of such custom-designed complexes including the ribosome, transcriptional machinery, motors and transporters, all of which work in a precisely organized manner. Knowledge of their properties is of crucial importance in bionanotechnology.

Joanna Trylska and her group explore the function, dynamics, and physical properties of macromolecular assemblies to understand their activities in the living cell. The main object of our studies is the ribosome - the molecular complex responsible for protein synthesis. The ultimate goal is to search for antibiotic analogs inhibiting the function of bacterial ribosomes.

Students interested in these topics and willing to do research on molecular machines please e-mail: bionano@icm.edu.pl

Interdisciplinary Centre for Mathematical and Computational Modelling University of Warsaw Żwirki i Wigury 93 02-089 Warsaw, Poland tel. +48 (22) 5540-843 fax +48 (22) 5540-801

Research funding

• ICM, University of Warsaw
• Polish Ministry of Science and Higher Education (3 T11F 005 30)
• Fogarty International Center (NIH Research Grant no R03 TW07318)
• Foundation for Polish Science (Focus programme)

Biomolecular Machines Laboratory logo by Chris Rychter