Research

Our research interests involve exploring the function, dynamics, and physico-chemical properties of nanoscale assemblies to understand their activities in the living cell. The main object of our studies is the ribosome - the macromolecular complex responsible for protein synthesis.

The focus of our research is to extend, apply and verify experimentally various simulation techniques to study the energetics and diffusional association of elongation factors, antibiotics and their proposed derivatives with the bacterial ribosome. The goal is to understand its internal motions, electrostatic properties, as well as the binding of antibiotics inhibiting its proper functioning. The techniques to explore the thermodynamics and kinetics of binding include all-atom and coarse-grained molecular dynamics,  Brownian dynamics and Poisson-Boltzmann implicit solvent models.

Ribosome projects	Coarse-grained models	Biomolecular electrostatics