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Team project
We are looking for enthusiastic researchers (Post-doc in experimental and/or theoretical biophysics) to work on a Team Project. See the announcement.
Project title: "Antisense peptide nucleic acids as inhibitors of bacterial translation"
The main objective of the Team project is to apply both computational and experimental techniques to design specific peptide nucleic acid (PNA) derivatives that will target the ribosomal RNA and inhibit bacterial translation.
Project period: Nov 2009 - Oct 2013
Research partners:
- University of California at San Diego, CA,
- University of Virginia, Charlottesville, VA,
- NEST, Scuola Normale Superiore, Pisa, Italy
The Team project group will work on the following topics:
- design PNA based compounds targeting ribosomal RNA, determine their mode of binding and estimate their energetics and kinetics of binding,
- perform molecular dynamics simulations of ribosomal RNA,
- improve the methodology to describe nucleic acid - ligand interactions,
- develop coarse-grained models for nucleic acids,
- design and perform experiments to study association of ligands with RNA and the ribosome,
- experiments to determine inhibitor potency on ribosomes and growth inhibition checks of bacteria.
